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PACAP Stimulates Biosynthesis and Release of Endozepines from Rat Astrocytes

Abstract : Astrocytes synthesize and release endozepines, a family of neuropeptides related to diazepam-binding inhibitor (DBI). Astroglial cells also express the receptors of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP). In the present article, we show that PACAP dose dependently increases DBI gene expression and stimulates endozepine release through activation of PAC1-R. PACAP increases cAMP formation, enhances polyphosphoinositide turnover, and evokes calcium mobilization from intracellular Ca2+ pools. The effect of PACAP on endozepine release is mediated through the adenylyl cyclase/PKA pathway while the downregulation of astrocyte response to PACAP can be ascribed to activation of the PLC/PKC pathway.
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Contributor : Jérôme Leprince Connect in order to contact the contributor
Submitted on : Tuesday, January 8, 2019 - 10:06:28 AM
Last modification on : Wednesday, December 8, 2021 - 3:09:22 AM

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Olfa Masmoudi-Kouki, Pierrick Gandolfo, Jérôme Leprince, David Vaudry, Georges Pelletier, et al.. PACAP Stimulates Biosynthesis and Release of Endozepines from Rat Astrocytes. Annals of the New York Academy of Sciences, Wiley, 2006, 1070 (1), pp.411-416. ⟨10.1196/annals.1317.094⟩. ⟨hal-01973027⟩



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