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Journal articles
PACAP Stimulates Biosynthesis and Release of Endozepines from Rat Astrocytes
Abstract : Astrocytes synthesize and release endozepines, a family of neuropeptides related to diazepam-binding inhibitor (DBI). Astroglial cells also express the receptors of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP). In the present article, we show that PACAP dose dependently increases DBI gene expression and stimulates endozepine release through activation of PAC1-R. PACAP increases cAMP formation, enhances polyphosphoinositide turnover, and evokes calcium mobilization from intracellular Ca2+ pools. The effect of PACAP on endozepine release is mediated through the adenylyl cyclase/PKA pathway while the downregulation of astrocyte response to PACAP can be ascribed to activation of the PLC/PKC pathway.
https://hal-normandie-univ.archives-ouvertes.fr/hal-01973027
Contributor : Jérôme Leprince <>
Submitted on : Tuesday, January 8, 2019 - 10:06:28 AM
Last modification on : Wednesday, October 28, 2020 - 9:52:05 AM
Contributor : Jérôme Leprince <>
Submitted on : Tuesday, January 8, 2019 - 10:06:28 AM
Last modification on : Wednesday, October 28, 2020 - 9:52:05 AM
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