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Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

Abstract : Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01962819
Contributor : Jérôme Leprince <>
Submitted on : Thursday, December 20, 2018 - 7:11:21 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM

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Jean-Claude Le Mevel, Frédéric Lancien, Nagi Mimassi, Jérôme Leprince, J Michael Conlon, et al.. Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout. Peptides, Elsevier, 2008, 29 (5), pp.830-837. ⟨10.1016/j.peptides.2007.06.020⟩. ⟨hal-01962819⟩

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