Skip to Main content Skip to Navigation
Journal articles

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

Abstract : Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01962802
Contributor : Jérôme Leprince <>
Submitted on : Thursday, December 20, 2018 - 6:54:26 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM

Links full text

Identifiers

Citation

Damien Lanfray, Alexandre Caron, Marie-Claude Roy, Mathieu Laplante, Fabrice Morin, et al.. Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. eLife, eLife Sciences Publication, 2016, 5, ⟨10.7554/eLife.11742⟩. ⟨hal-01962802⟩

Share

Metrics

Record views

83