Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice - Archive ouverte HAL Access content directly
Journal Articles eLife Year : 2016

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

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Abstract

Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.

Dates and versions

hal-01962802 , version 1 (20-12-2018)

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Damien Lanfray, Alexandre Caron, Marie-Claude Roy, Mathieu Laplante, Fabrice Morin, et al.. Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. eLife, 2016, 5, ⟨10.7554/eLife.11742⟩. ⟨hal-01962802⟩
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