Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide

Karine Glinel (1) , Alain Jonas , Thierry Jouenne (2) , Ludovic Galas (3) , Wilhelm Huck , Jérôme Leprince (4, 5, 6)

1 UCL - Université Catholique de Louvain = Catholic University of Louvain
2 PBM - Polymères, biopolymères, membranes
3 PRIMACEN - Plate-Forme de Recherche en Imagerie Cellulaire de Haute-Normandie
4 Neuroendocrinologie cellulaire et moléculaire
5 DC2N - Différenciation et communication neuronale et neuroendocrine
6 DC2N - Différenciation et communication neuronale et neuroendocrine

Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Pharmaceutical sciences; Pharmacology

Karine Glinel, Alain Jonas, Thierry Jouenne, Ludovic Galas, Wilhelm Huck, et al.. Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide. Bioconjugate Chemistry, 2009, 20 (1), pp.71-77. ⟨10.1021/bc800280u⟩. ⟨hal-01962744⟩