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Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide

Karine Glinel 1 Alain Jonas Thierry Jouenne 2 Ludovic Galas 3 Wilhelm Huck Jérôme Leprince 4, 5, 6 
1 UCL - Université Catholique de Louvain = Catholic University of Louvain
2 PBM - Polymères, biopolymères, membranes
3 PRIMACEN - Plate-Forme de Recherche en Imagerie Cellulaire de Haute-Normandie
UNIROUEN - Université de Rouen Normandie, IRIB - Institute for Research and Innovation in Biomedicine, HeRacLeS - High-tech Research Infrastructures for Life Sciences
4 Neuroendocrinologie cellulaire et moléculaire
5 DC2N - Différenciation et communication neuronale et neuroendocrine
6 DC2N - Différenciation et communication neuronale et neuroendocrine
Abstract : Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01962744
Contributor : Jérôme Leprince Connect in order to contact the contributor
Submitted on : Thursday, December 20, 2018 - 6:18:49 PM
Last modification on : Thursday, September 1, 2022 - 11:08:21 AM

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CNRS | INSA-ROUEN | COMUE-NORMANDIE | UNIROUEN | DC2N | INSA-GROUPE | PBS | DEESSE

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Karine Glinel, Alain Jonas, Thierry Jouenne, Ludovic Galas, Wilhelm Huck, et al.. Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide. Bioconjugate Chemistry, American Chemical Society, 2009, 20 (1), pp.71-77. ⟨10.1021/bc800280u⟩. ⟨hal-01962744⟩

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