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Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide

Abstract : Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01962744
Contributor : Jérôme Leprince <>
Submitted on : Thursday, December 20, 2018 - 6:18:49 PM
Last modification on : Wednesday, July 1, 2020 - 1:24:02 PM

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Karine Glinel, Alain Jonas, Thierry Jouenne, Ludovic Galas, Wilhelm Huck, et al.. Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide. Bioconjugate Chemistry, American Chemical Society, 2009, 20 (1), pp.71-77. ⟨10.1021/bc800280u⟩. ⟨hal-01962744⟩

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