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Article Dans Une Revue Bioconjugate Chemistry Année : 2009

Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide

Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival.

Fabrice Morin
  • Fonction : Auteur
Pierre Michael Coly
  • Fonction : Auteur
Marie-Laure Walet-Balieu
Sami Zekri
  • Fonction : Auteur
Hélène Castel
Olfa Masmoudi-Kouki
  • Fonction : Auteur
  • PersonId : 976009
Alain Jonas
  • Fonction : Auteur
Thierry Jouenne
Wilhelm Huck
  • Fonction : Auteur

Résumé

Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.
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Dates et versions

hal-01962743 , version 1 (20-12-2018)

Identifiants

Citer

Ikram Ghouili, Seyma Bahdoudi, Fabrice Morin, Fatma Amri, Yosra Hamdi, et al.. Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide. Bioconjugate Chemistry, 2009, 20 (1), pp.71-77. ⟨10.1021/bc800280u⟩. ⟨hal-01962743⟩
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