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26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas

Abstract : 26RFa is a novel orexigenic neuropeptide identified as the endogenous ligand of the orphan G protein-coupled receptor GPR103. GPR103 shares sequence identity with the receptors for neuropeptide-Y and galanin, two peptides known to inhibit insulin secretion. We have investigated the effect of 26RFa on insulin and glucagon secretion in the perfused rat pancreas. 26RFa dose-dependently reduced glucose-induced insulin release, inhibited the insulin responses to both arginine and exendin-4 and did not affect glucagon output. The inhibitory effect of 26RFa on exendin-4-induced insulin secretion was not observed in pancreata from pertussis toxin-treated rats, thus suggesting that 26RFa may inhibit insulin secretion, at least in part, via a pertussis toxin-sensitive G(i) protein coupled to the adenylyl cyclase system.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01962727
Contributor : Jérôme Leprince <>
Submitted on : Thursday, December 20, 2018 - 6:05:58 PM
Last modification on : Thursday, February 7, 2019 - 5:42:52 PM

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Eva Egido, Raquel Hernandez, Jérôme Leprince, Nicolas Chartrel, Hubert Vaudry, et al.. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides, Elsevier, 2007, 28 (4), pp.725-730. ⟨10.1016/j.peptides.2006.04.004⟩. ⟨hal-01962727⟩

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