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Behavioral actions of urotensin-II

Abstract : Urotensin-II (U-II) and urotensin-II-related peptide (URP) have been identified as the endogenous ligands of the orphan G-protein-coupled receptor GPR14 now renamed UT. The occurrence of U-II and URP in the central nervous system, and the widespread distribution of UT in the brain suggest that U-II and URP may play various behavioral activities. Studies conducted in rodents have shown that central administration of U-II stimulates locomotion, provokes anxiety- and depressive-like states, enhances feeding activity and increases the duration of paradoxical sleep episodes. These observations indicate that, besides the endocrine/paracrine activities of U-II and URP on cardiovascular and kidney functions, these peptides may act as neurotransmitters and/or neuromodulators to regulate various neurobiological activities.
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Contributor : Jérôme Leprince <>
Submitted on : Thursday, December 20, 2018 - 6:03:08 PM
Last modification on : Wednesday, July 1, 2020 - 1:24:03 PM

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Jean Do Rego, Jérôme Leprince, Elizabeth Scalbert, Hubert Vaudry, Jean Costentin, et al.. Behavioral actions of urotensin-II. Peptides, Elsevier, 2008, 29 (5), pp.838-844. ⟨10.1016/j.peptides.2007.12.016⟩. ⟨hal-01962721⟩

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