HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Behavioral effects of urotensin-II centrally administered in mice

Abstract : Urotensin-II (U-II) receptors are widely distributed in the central nervous system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, the behavioral effects of centrally administered U-II have received little attention. In the present study, we tested the effects of i.c.v. injections of U-II on behavioral, metabolic, and endocrine responses in mice. Administration of graded doses of U-II (1-10,000 ng/mouse) provoked: (1) a dose-dependent reduction in the number of head dips in the hole-board test; (2) a dose-dependent reduction in the number of entries in the white chamber in the black-and-white compartment test, and in the number of entries in the central platform and open arms in the plus-maze test; and (3) a dose-dependent increase in the duration of immobility in the forced-swimming test and tail suspension test. Intracerebroventricular injection of U-II also caused an increase in: food intake at doses of 100 and 1,000 ng/mouse, water intake at doses of 100-10,000 ng/mouse, and horizontal locomotion activity at a dose of 10,000 ng/mouse. Whatever was the dose, the central administration of U-II had no effect on body temperature, nociception, apomorphine-induced penile erection and climbing behavior, and stress-induced plasma corticosterone level. Taken together, the present study demonstrates that the central injection of U-II at doses of 1-10,000 ng/mouse induces anxiogenic- and depressant-like effects in mouse. These data suggest that U-II may be involved in some aspects of psychiatric disorders.
Complete list of metadata

Contributor : Jérôme Leprince Connect in order to contact the contributor
Submitted on : Thursday, December 20, 2018 - 5:58:52 PM
Last modification on : Wednesday, December 8, 2021 - 3:09:21 AM

Links full text



Jean-Claude Do-Rego, David Chatenet, Marie-Hélène Orta, Bertrand Naudin, Camille Le Cudennec, et al.. Behavioral effects of urotensin-II centrally administered in mice. Psychopharmacology, Springer Verlag, 2005, 183 (1), pp.103-117. ⟨10.1007/s00213-005-0140-2⟩. ⟨hal-01962710⟩



Record views