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In vivo action of a new octadecaneuropeptide (ODN) antagonist on gonadotropin-releasing hormone gene expression in the male rat brain

Abstract : It has been reported that several of the effects induced by octadecaneuropeptide (ODN) could be mediated by an activation of a metabotropic receptor. In order to investigate the role and mechanism of action of ODN in gonadotropin-releasing hormone (GnRH) neuron regulation, we studied the effects of the acute i.c.v. administration of ODN and of a new ODN antagonist to metabotropic receptor, cyclo(1-8)[Dleu(5)]OP, on GnRH mRNA expression as evaluated by in situ hybridization in castrated male rats. The administration of ODN produced a decrease in the hybridization signal while the administration of cyclo(1-8)[Dleu(5)]OP alone produced an 18% increase. When administrated concomitantly with ODN, the antagonist both inhibited the depressing effect of ODN and induced a 22% increase over the values detected in ODN-treated rats. The data suggest that the effect of ODN on GnRH mRNA expression might be mediated by interaction with metabotropic receptors.
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Contributor : Jérôme Leprince Connect in order to contact the contributor
Submitted on : Wednesday, December 19, 2018 - 3:53:34 PM
Last modification on : Wednesday, March 2, 2022 - 3:48:01 PM

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M Compère, S. Li, Jérôme Leprince, M.C Tonon, H. Vaudry, et al.. In vivo action of a new octadecaneuropeptide (ODN) antagonist on gonadotropin-releasing hormone gene expression in the male rat brain. Neuroscience, Elsevier - International Brain Research Organization, 2004, 125 (2), pp.411-415. ⟨10.1016/j.neuroscience.2004.02.016⟩. ⟨hal-01960863⟩

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