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Journal articles
In vivo action of a new octadecaneuropeptide (ODN) antagonist on gonadotropin-releasing hormone gene expression in the male rat brain
Abstract : It has been reported that several of the effects induced by octadecaneuropeptide (ODN) could be mediated by an activation of a metabotropic receptor. In order to investigate the role and mechanism of action of ODN in gonadotropin-releasing hormone (GnRH) neuron regulation, we studied the effects of the acute i.c.v. administration of ODN and of a new ODN antagonist to metabotropic receptor, cyclo(1-8)[Dleu(5)]OP, on GnRH mRNA expression as evaluated by in situ hybridization in castrated male rats. The administration of ODN produced a decrease in the hybridization signal while the administration of cyclo(1-8)[Dleu(5)]OP alone produced an 18% increase. When administrated concomitantly with ODN, the antagonist both inhibited the depressing effect of ODN and induced a 22% increase over the values detected in ODN-treated rats. The data suggest that the effect of ODN on GnRH mRNA expression might be mediated by interaction with metabotropic receptors.
https://hal-normandie-univ.archives-ouvertes.fr/hal-01960863
Contributor : Jérôme Leprince <>
Submitted on : Wednesday, December 19, 2018 - 3:53:34 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM
Contributor : Jérôme Leprince <>
Submitted on : Wednesday, December 19, 2018 - 3:53:34 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM
