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Journal articles
Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals
Nicolas Chartrel
1
Federica Bruzzone
Cynthia Dujardin
Jérôme Leprince
2, 3, 1
Helene Tollemer
Youssef Anouar
3
Mauro Vallarino
Jean Costentin
4
Hubert Vaudry
2
Nicolas Chartrel 1
Author
Federica Bruzzone
Author
Cynthia Dujardin
Author
Jérôme Leprince 2, 3, 1
Author IdHAL : jerome-leprince ORCID : https://orcid.org/0000-0002-7814-9927
Hubert Vaudry 2
Author
1
DC2N - Différenciation et communication neuronale et neuroendocrine (Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex - France)
- UNIROUEN - Université de Rouen Normandie : U1239 (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1239 (101, rue de Tolbiac, 75013 Paris - France)
2
Neuroendocrinologie cellulaire et moléculaire (Universite de Rouen 76821 MONT-SAINT-AIGNAN CEDEX - France)
- UNIROUEN - Université de Rouen Normandie : U413 (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U413 (101, rue de Tolbiac, 75013 Paris - France)
3
DC2N - Différenciation et communication neuronale et neuroendocrine (Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex - France)
- UNIROUEN - Université de Rouen Normandie : U982 (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U982 (101, rue de Tolbiac, 75013 Paris - France)
4
Neuropsycho-pharmacologie expérimentale (Faculté de Médecine et Pharmacie 22 boulevard Gambetta 76183 ROUEN CEDEX - France)
- CNRS - Centre National de la Recherche Scientifique : FRE 2735 (France)
- UNIROUEN - Université de Rouen Normandie (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
Abstract : In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
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Journal articles
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01960805
Contributor : Jérôme Leprince <>
Submitted on : Wednesday, December 19, 2018 - 3:38:05 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM
Contributor : Jérôme Leprince <>
Submitted on : Wednesday, December 19, 2018 - 3:38:05 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM
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- HAL Id : hal-01960805, version 1
- DOI : 10.1196/annals.1327.009
- PUBMED : 15891009
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COMUE-NORMANDIE | CNRS | UNIROUEN | DC2N
Citation
Nicolas Chartrel, Federica Bruzzone, Cynthia Dujardin, Jérôme Leprince, Helene Tollemer, et al.. Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals. Annals of the New York Academy of Sciences, Wiley, 2005, 1040 (1), pp.80-83. ⟨10.1196/annals.1327.009⟩. ⟨hal-01960805⟩
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