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Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals

Nicolas Chartrel 1 Federica Bruzzone Cynthia Dujardin Jérôme Leprince 2, 3, 1 Helene Tollemer Youssef Anouar 3 Mauro Vallarino Jean Costentin 4 Hubert Vaudry 2
1 DC2N - Différenciation et communication neuronale et neuroendocrine
2 Neuroendocrinologie cellulaire et moléculaire
3 DC2N - Différenciation et communication neuronale et neuroendocrine
4 Neuropsycho-pharmacologie expérimentale
Abstract : In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01960805
Contributor : Jérôme Leprince <>
Submitted on : Wednesday, December 19, 2018 - 3:38:05 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM

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COMUE-NORMANDIE | CNRS | UNIROUEN | DC2N

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Nicolas Chartrel, Federica Bruzzone, Cynthia Dujardin, Jérôme Leprince, Helene Tollemer, et al.. Identification of 26RFa from Frog Brain: A Novel Hypothalamic Neuropeptide with Orexigenic Activity in Mammals. Annals of the New York Academy of Sciences, Wiley, 2005, 1040 (1), pp.80-83. ⟨10.1196/annals.1327.009⟩. ⟨hal-01960805⟩

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