Investigations of octylglyceryl dextran- graft -poly(lactic acid) nanoparticles for peptide delivery to the brain

Asme Boussahel , Daniel Ibegbu , Rhita Lamtahri (1) , Julie Maucotel (2) , Julien Chuquet (1) , Benjamin Lefranc (1) , Jérôme Leprince (3, 4, 1) , Marta Roldo , Jean-Claude Le Mével , Darek Gorecki , Eugen Barbu (5) , Julie Chuquet

1 DC2N - Différenciation et communication neuronale et neuroendocrine
2 International Associated laboratory Samuel de Champlain
3 Neuroendocrinologie cellulaire et moléculaire
4 DC2N - Différenciation et communication neuronale et neuroendocrine
5 LITIS - Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes

Develop modified dextran nanoparticles showing potential to assist with drug permeation across the blood-brain barrier for the delivery of neuropeptides.

Keywords: brain; dextran; drug delivery; nanoparticles; neuropeptides

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Pharmaceutical sciences; Pharmacology

Asme Boussahel, Daniel Ibegbu, Rhita Lamtahri, Julie Maucotel, Julien Chuquet, et al.. Investigations of octylglyceryl dextran- graft -poly(lactic acid) nanoparticles for peptide delivery to the brain. Nanomedicine, 2017, 12 (8), pp.879-892. ⟨10.2217/nnm-2016-0406⟩. ⟨hal-01960722⟩