Thioether bond formation by SPASM domain radical SAM enzymes: C α H-atom abstraction in subtilosin A biosynthesis - Archive ouverte HAL Access content directly
Journal Articles Chemical Communications Year : 2016

Thioether bond formation by SPASM domain radical SAM enzymes: C α H-atom abstraction in subtilosin A biosynthesis

Abstract

AlbA is a radical SAM enzyme catalyzing the formation of three unusual thioether bonds in the antibiotic subtilosin A. We demonstrate here that AlbA catalyzes direct Cα H-atom abstraction and likely contains three essential [4Fe-4S] centers. This leads us to propose novel mechanistic perspectives for thioether bond catalysis by radical SAM enzymes.
Fichier principal
Vignette du fichier
c6cc01317a.pdf (1.98 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-01960692 , version 1 (31-05-2022)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Alhosna Benjdia, Alain Guillot, Benjamin Lefranc, Hubert Vaudry, Jérôme Leprince, et al.. Thioether bond formation by SPASM domain radical SAM enzymes: C α H-atom abstraction in subtilosin A biosynthesis. Chemical Communications, 2016, 52 (37), pp.6249-6252. ⟨10.1039/c6cc01317a⟩. ⟨hal-01960692⟩
131 View
10 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More