The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of androgeno-independent prostate cancer cells

Jessy Alonzeau (1) , David Alexandre (2) , Lydie Jeandel (2) , Maïte Courel (3) , Coralie Hautot (2) , Fatima-Zohra El Yamani , Françoise Gobet (4) , Jérôme Leprince (5, 2, 6) , Rabia Magoul (7) , Afaf Amarti (8) , Christian Pfister (9) , Laurent Yon (2) , Youssef Anouar (2) , Nicolas Chartrel (6) , Fatima-Zohra El Yamani

1 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
2 DC2N - Différenciation et communication neuronale et neuroendocrine
3 LBD-E14 - Compartimentation et trafic intracellulaire des mRNP = Compartmentation and intracellular traffic of mRNPs
4 Service d'Anatomie et Cytologie Pathologique [CHU Rouen]
5 Neuroendocrinologie cellulaire et moléculaire
6 DC2N - Différenciation et communication neuronale et neuroendocrine
7 USMBA - Université Sidi Mohamed Ben Abdellah
8 CHU HII - Centre Hospitalier Universitaire Hassan II
9 Service d'urologie [Rouen]

Accumulating data suggest that neuropeptides produced by neuroendocrine cells play a crucial role in the progression and aggressiveness of hormone refractory prostate cancer (CaP). In this study, we have investigated the presence and function of the neuropeptide 26RFa in CaP.

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Pharmaceutical sciences; Pharmacology

Jessy Alonzeau, David Alexandre, Lydie Jeandel, Maïte Courel, Coralie Hautot, et al.. The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of androgeno-independent prostate cancer cells. European Journal of Cancer, 2013, 49 (2), pp.511-519. ⟨10.1016/j.ejca.2012.05.028⟩. ⟨hal-01960628⟩