Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells

Mickael Diallo 1 Marie-Thérèse Schouft 2 Marc Fontaine 2 Elisabeth Scalbert Maria Malagon 3 Pierrick Gandolfo 1 Romain Castilleux 4 Barbara Plancot 4 Marc Ropitaux 4 Alexis Carreras 5 Isabelle Boulogne 6 Marie-Laure Follet-Gueye 4 Zoë Popper 7 Azeddine Driouich 4 Maïté Vicré 4 Laurence Desrues 1 Eric Cellier 8 Annick Decker Stefan Clerens Frans Vandesande C. Do-Rego C. Beauvillain Marc Baroncini 9 Richard Balment Cynthia Dujardin Helene Tollemer Federica Bruzzone Hélène Tollemer Jean Do-Régo Pascal Cosette 10 Thierry Jouenne 11 Guy Simonnet 12 Mauro Vallarino Jean Beauvillain Jean Costentin 13 Jean-Claude Do-Régo Jean-Claude Beauvillain 9 C Chartrel P Alvear-Perez X. Iturrioz A. Reaux-Le Goazigo 14 V. Audinot C Chomarat C Coge O. Nosjean 15 M. Rodriguez 16 J. Galizzi R. Goazigo P. Chomarat F. Coge Nicolas Chartrel 17 Jessy Alonzeau 18 David Alexandre 1 Jean Jeandel Rodrigo Alvear-Perez 19 Jean Boutin 20 Youssef Anouar 1 Catherine Llorens-Cortes 19 Lydie Jeandel 1 Ludovic Carlier 21 Isabelle Ségalas-Milazzo 22 Laure Guilhaudis 23 Hassan Oulyadi 22 Daniel Davoust 23 Christophe Dubessy 24 Elizabeth Scalbert Bruno Pfeiffer 25 Pierre Renard 26 Isabelle Lihrmann 1 Pierre Pacaud 27 Lucie Chevrier 28 Alexandre De Brevern 29 Eva Hernandez Anne Marie Guedj 30 Nicolas De Roux 31 V Cholez V Debuysscher B Bourgeais B Boudot F. Tron 32 B. Brassart 33 A. Regnier 34 E Bissac E Pecnard F. Gouilleux 35 K Lassoued V Gouilleux-Gruart E Cholez J Bourgeais C. Boudot 36 V Gouilleux Julien Chuquet 17 Clotilde Lecrux David Chatenet 37 Laurent Chazalviel Simon Roussel 38 Eric Mackenzie Omar Touzani 39 M.C Tonon S. Li 40 J�r�me Leprince 32 M.C. Tonon M Compère D Lanfray Hélène Castel 41 M. Morin 42 Jérôme Leprince 2, 1, 17 B Dureuil Hubert Vaudry 2 G. Pelletier 43 Marie-Christine Tonon 1 V. Compère F. Morin 44 D Dureuil V Vaudry
23 ECOBS - Equipe de Chimie Organique et Biologie Structurale
INSA Rouen Normandie - Institut national des sciences appliquées Rouen Normandie
40 ING - IRCELYON-Ingéniérie, du matériau au réacteur
IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon
Abstract : In the central nervous system of mammals, the gene encoding diazepam-binding inhibitor (DBI) is exclusively expressed in glial cells. Previous studies have shown that central administration of a DBI processing product, the octadecaneuropeptide ODN, causes a marked inhibition of food consumption in rodents. Paradoxically, however, the effect of food restriction on DBI gene expression has never been investigated. Here, we show that in mice, acute fasting dramatically reduces DBI mRNA levels in the hypothalamus and the ependyma bordering the third and lateral ventricles. I.p. injection of insulin, but not of leptin, selectively stimulated DBI expression in the lateral ventricle area. These data support the notion that glial cells, through the production of endozepines, may relay peripheral signals to neurons involved in the central regulation of energy homeostasis.
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Contributeur : Jérôme Leprince <>
Soumis le : mercredi 19 décembre 2018 - 14:30:59
Dernière modification le : lundi 18 mars 2019 - 16:25:46

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Mickael Diallo, Marie-Thérèse Schouft, Marc Fontaine, Elisabeth Scalbert, Maria Malagon, et al.. Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells. Journal of Molecular Endocrinology, BioScientifica, 2010, 44 (5), pp.295-299. 〈10.1677/JME-09-0176〉. 〈hal-01960557〉

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