Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells

Marie-Thérèse Schouft 1 Marc Fontaine 1 Elisabeth Scalbert Maria Malagon 2 Pierrick Gandolfo 3 Laurence Desrues 3 Eric Cellier 4 Annick Decker Stefan Clerens Frans Vandesande C. Do-Rego C. Beauvillain Marc Baroncini 5 Richard Balment Cynthia Dujardin Helene Tollemer Federica Bruzzone Hélène Tollemer Jean Do-Régo Guy Simonnet 6 Mauro Vallarino Jean Beauvillain Jean Costentin 7 Jean-Claude Do-Régo Jean-Claude Beauvillain 5 C Chartrel P Alvear-Perez X. Iturrioz A. Reaux-Le Goazigo 8 V. Audinot C Chomarat C Coge O. Nosjean 9 M. Rodriguez 10 J. Galizzi R. Goazigo P. Chomarat F. Coge Nicolas Chartrel 11 Jessy Alonzeau 12 David Alexandre 3 Jean Jeandel Rodrigo Alvear-Perez 13 Jean Boutin 14 Youssef Anouar 3 Catherine Llorens-Cortes 13 Lydie Jeandel 3 Ludovic Carlier 15 Isabelle Ségalas-Milazzo 16 Laure Guilhaudis 17 Hassan Oulyadi 16 Daniel Davoust 17 Christophe Dubessy 18 Elizabeth Scalbert Bruno Pfeiffer 19 Pierre Renard 20 Isabelle Lihrmann 3 Pierre Pacaud 21 Lucie Chevrier 22 Alexandre de Brevern 23 Eva Hernandez Anne Marie Guedj 24 Nicolas de Roux 25 V Cholez V Debuysscher B Bourgeais B Boudot F. Tron 26 B. Brassart 27 A. Regnier 28 E Bissac E Pecnard F. Gouilleux 29 K Lassoued V Gouilleux-Gruart E Cholez J Bourgeais C. Boudot 30 V Gouilleux Julien Chuquet 11 Clotilde Lecrux David Chatenet 31 Laurent Chazalviel Simon Roussel 32 Eric Mackenzie Omar Touzani 33 M.C Tonon S. Li 34 J�r�me Leprince 26 M.C. Tonon M Compère D Lanfray Hélène Castel 35 M. Morin 36 Jérôme Leprince 1, 3, 11 B Dureuil Hubert Vaudry 1 G. Pelletier 37 Marie-Christine Tonon 3 V. Compère F. Morin 38 D Dureuil V Vaudry
17 ECOBS - Equipe de Chimie Organique et Biologie Structurale
INSA Rouen Normandie - Institut national des sciences appliquées Rouen Normandie
34 ING - IRCELYON-Ingéniérie, du matériau au réacteur
IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon
Abstract : In the central nervous system of mammals, the gene encoding diazepam-binding inhibitor (DBI) is exclusively expressed in glial cells. Previous studies have shown that central administration of a DBI processing product, the octadecaneuropeptide ODN, causes a marked inhibition of food consumption in rodents. Paradoxically, however, the effect of food restriction on DBI gene expression has never been investigated. Here, we show that in mice, acute fasting dramatically reduces DBI mRNA levels in the hypothalamus and the ependyma bordering the third and lateral ventricles. I.p. injection of insulin, but not of leptin, selectively stimulated DBI expression in the lateral ventricle area. These data support the notion that glial cells, through the production of endozepines, may relay peripheral signals to neurons involved in the central regulation of energy homeostasis.
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Contributeur : Jérôme Leprince <>
Soumis le : mercredi 19 décembre 2018 - 14:30:59
Dernière modification le : mardi 21 mai 2019 - 16:18:11

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Marie-Thérèse Schouft, Marc Fontaine, Elisabeth Scalbert, Maria Malagon, Pierrick Gandolfo, et al.. Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells. Journal of Molecular Endocrinology, BioScientifica, 2010, 44 (5), pp.295-299. ⟨10.1677/JME-09-0176⟩. ⟨hal-01960557⟩

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