Skip to Main content Skip to Navigation
Patents

Method of resolution of two enantiomers by crystallization

Abstract : method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-defined kinetic schedule. A racemic mixture of fine particle size is added to the mother liquors obtained after harvesting the crystals, the mother liquors then being heated to a temperature lower than that of homogenization of the solution so that excess enantiomer is present only in a solid state in equilibrium with the solution. Further cooling produces the other enantiomer and completes the cycle of operations which may then be carried out repetitively.
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01949911
Contributor : Aurélien Lemercier <>
Submitted on : Monday, December 10, 2018 - 2:40:01 PM
Last modification on : Monday, December 2, 2019 - 2:44:06 PM

Identifiers

  • HAL Id : hal-01949911, version 1

Citation

Gérard Coquerel, Marie-Noëlle Petit, Roger Bouaziz. Method of resolution of two enantiomers by crystallization. France, Patent n° : WO1995008522A1. 1993. ⟨hal-01949911⟩

Share

Metrics

Record views

18