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Method of resolution of two enantiomers by crystallization

Abstract : method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-defined kinetic schedule. A racemic mixture of fine particle size is added to the mother liquors obtained after harvesting the crystals, the mother liquors then being heated to a temperature lower than that of homogenization of the solution so that excess enantiomer is present only in a solid state in equilibrium with the solution. Further cooling produces the other enantiomer and completes the cycle of operations which may then be carried out repetitively.
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Submitted on : Monday, December 10, 2018 - 2:40:01 PM
Last modification on : Wednesday, March 9, 2022 - 3:56:04 PM


  • HAL Id : hal-01949911, version 1


Gérard Coquerel, Marie-Noëlle Petit, Roger Bouaziz. Method of resolution of two enantiomers by crystallization. France, Patent n° : WO1995008522A1. 1993. ⟨hal-01949911⟩



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