Method for splitting omeprazole salts

Gérard Coquerel (1) , Guillaume Tauvel (1) , Marie-Noelle Petit (1)

1 SMS - Sciences et Méthodes Séparatives

The invention relates to the splitting by preferable crystallisation of potassium salts of omeprazole racemic solvate of ethanol and/or ethyleneglycol, that comprises transforming the omeprazole into a potassium salt in the form of a solvate or a mixture of these solvates in the presence of an excess of a mineral base defining a potassium source, said potassium salts being in the form of conglomerates, and splitting said conglomerates independently or simultaneously by preferable crystallisation for separating the two enantiomers (S) and (R) of the potassium salts from the omeprazole.

Domaines: Matériaux; Cristallographie; Chimie organique

Gérard Coquerel, Guillaume Tauvel, Marie-Noelle Petit. Method for splitting omeprazole salts. France, Patent n° : WO2009027614A3. 2007. ⟨hal-01949579⟩