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Method for splitting omeprazole salts

Abstract : The invention relates to the splitting by preferable crystallisation of potassium salts of omeprazole racemic solvate of ethanol and/or ethyleneglycol, that comprises transforming the omeprazole into a potassium salt in the form of a solvate or a mixture of these solvates in the presence of an excess of a mineral base defining a potassium source, said potassium salts being in the form of conglomerates, and splitting said conglomerates independently or simultaneously by preferable crystallisation for separating the two enantiomers (S) and (R) of the potassium salts from the omeprazole.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01949579
Contributor : Aurélien Lemercier <>
Submitted on : Monday, December 10, 2018 - 11:25:17 AM
Last modification on : Monday, December 2, 2019 - 2:44:05 PM

Identifiers

  • HAL Id : hal-01949579, version 1

Citation

Gérard Coquerel, Guillaume Tauvel, Marie-Noelle Petit. Method for splitting omeprazole salts. France, Patent n° : WO2009027614A3. 2007. ⟨hal-01949579⟩

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