Does Somatostatin Have a Role in the Regulation of Cortisol Secretion in Primary Pigmented Nodular Adrenocortical Disease (PPNAD)? A Clinical and in Vitro Investigation

Zakariae Bram (1) , Paraskevi Xekouki , Estelle Louiset (1, 2, 3, 4, 5) , Meg Keil , Dimitrios Avgeropoulos , Christoforos Giatzakis , Maria Nesterova , Ninet Sinaii , Leo Hofland , Rabia Cherqaoui , Hervé Lefebvre (1, 2, 6, 3) , Constantine A. Stratakis (7)

1 DC2N - Différenciation et communication neuronale et neuroendocrine
2 DC2N - Différenciation et communication neuronale et neuroendocrine
3 UNIROUEN - Université de Rouen Normandie
4 Neuroendocrinologie cellulaire et moléculaire
5 INSERM - Institut National de la Santé et de la Recherche Médicale
6 CHU Rouen
7 Section on Endocrinology and Genetics

Somatostatin (SST) receptors (SSTRs) are expressed in a number of tissues, including the adrenal cortex, but their role in cortisol secretion has not been well characterized.

Domains: Life Sciences [q-bio]; Human health and pathology; Endocrinology and metabolism; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Human health and pathology; Tissues and Organs [q-bio.TO]

Zakariae Bram, Paraskevi Xekouki, Estelle Louiset, Meg Keil, Dimitrios Avgeropoulos, et al.. Does Somatostatin Have a Role in the Regulation of Cortisol Secretion in Primary Pigmented Nodular Adrenocortical Disease (PPNAD)? A Clinical and in Vitro Investigation. Journal of Clinical Endocrinology and Metabolism, 2014, 99 (5), pp.E891-E901. ⟨10.1210/jc.2013-2657⟩. ⟨hal-01946264⟩