Reversal of a Blunted Follicle-Stimulating Hormone by Chemotherapy in an Inhibin B–Secreting Adrenocortical Carcinoma

Stéphanie Espiard (1) , Najiba Lahlou (2) , Mathilde Sibony (3) , Estelle Louiset (4, 5, 6, 7, 8) , Marie Bienvenu , Jérôme Bertherat (1, 9, 10) , Bertrand Dousset (11, 12, 1, 10) , Lionel Groussin (1, 9, 10) , Rossella Libé (11, 9)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 Laboratoire de Biologie hormonale
3 Service d'Anatomie et cytologie pathologiques [CHU Tenon]
4 UNIROUEN - Université de Rouen Normandie
5 DC2N - Différenciation et communication neuronale et neuroendocrine
6 DC2N - Différenciation et communication neuronale et neuroendocrine
7 Neuroendocrinologie cellulaire et moléculaire
8 INSERM - Institut National de la Santé et de la Recherche Médicale
9 EMD - [Institut Cochin] Département Endocrinologie, métabolisme, diabète (EMD)
10 UPD5 - Université Paris Descartes - Paris 5
11 Hôpital Cochin [AP-HP]
12 Service de gynécologie et d'endocrinologie [CHU Cochin]

Adrenocortical carcinomas (ACCs) are revealed in 60% of cases by steroid hypersecretion. Alternatively, it is uncommon to observe a paraneoplastic syndrome due to a peptide oversecretion.

Keywords: adrenocortical carcinoma; inhibin B; tumor marker

Domains: Life Sciences [q-bio]; Human health and pathology; Endocrinology and metabolism; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Human health and pathology; Tissues and Organs [q-bio.TO]

Stéphanie Espiard, Najiba Lahlou, Mathilde Sibony, Estelle Louiset, Marie Bienvenu, et al.. Reversal of a Blunted Follicle-Stimulating Hormone by Chemotherapy in an Inhibin B–Secreting Adrenocortical Carcinoma. Journal of the Endocrine Society, 2017, 1 (1), pp.46-50. ⟨10.1210/js.2016-1009⟩. ⟨hal-01945843⟩