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Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells

Abstract : In human adrenal, serotonin (5-HT), produced by mast cells located in zona glomerulosa, stimulates production of corticosteroids through a paracrine mechanism involving the 5-HT receptor type 4 (5-HT4). The aim of the present study was to investigate the transduction mechanisms associated with activation of 5-HT4 receptors in human adrenocortical cells. Our results show that 5-HT4 receptors are present in the outer adrenal cortex, both in glomerulosa and fasciculata zonae. In the zona glomerulosa. 5-HT4 receptor was detected both in immunopositive and immunonegative cells for 11β-hydroxylase, an enzyme involved in cortisol synthesis. The data demonstrate that 5-HT4 receptors are positively coupled to adenylyl cyclases and cAMP-dependent protein kinases (PKA). The activation of the cAMP-PKA pathway is associated with calcium influx through T-type calcium channels. Both the adenylyl cyclase/PKA pathway and the calcium influx are involved in 5-HT-induced cortisol secretion.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01931437
Contributor : Céline Duparc <>
Submitted on : Thursday, November 22, 2018 - 5:44:42 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM

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Estelle Louiset, Céline Duparc, Sebastien Lenglet, Celso Gomez-Sanchez, Herve Lefebvre. Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Molecular and Cellular Endocrinology, Elsevier, 2017, 441, pp.99 - 107. ⟨10.1016/j.mce.2016.10.008⟩. ⟨hal-01931437⟩

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