Abnormal Sensitivity to Glucagon and Related Peptides in Primary Adrenal Cushing’s Syndrome

Estelle Louiset; Céline Duparc; Lionel Groussin; Françoise Gobet; Rachel Desailloud; G. Barrande; Y. Reznik; J. Bertherat; G. Prevost; Hervé Lefebvre

doi:10.1055/s-0034-1384522

Journal articles

Abnormal Sensitivity to Glucagon and Related Peptides in Primary Adrenal Cushing’s Syndrome

Estelle Louiset ^{1, 2} Céline Duparc ^{1, 2} Lionel Groussin ^{3, 4, 5, 6, 7} Françoise Gobet ⁸ Rachel Desailloud G. Barrande ⁹ Y. Reznik ¹⁰ J. Bertherat ^{4, 5, 3, 6, 7} G. Prevost ^{1, 2, 11} Hervé Lefebvre ^{1, 2, 11}

1 DC2N - Différenciation et communication neuronale et neuroendocrine

2 DC2N - Différenciation et communication neuronale et neuroendocrine

3 CHU Cochin [AP-HP]

4 IC UM3 (UMR 8104 / U1016) - Institut Cochin

5 EMD - [Institut Cochin] Département Endocrinologie, métabolisme, diabète (EMD)

6 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)

7 UPD5 - Université Paris Descartes - Paris 5

8 Service d'Anatomie et Cytologie Pathologique [CHU Rouen]

9 CHR - Centre Hospitalier Régional d'Orléans

10 Service d'Endocrinologie

11 Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen]

Abstract : Illegitimate G-protein coupled receptors are known to control cortisol secretion in adrenal adenomas and bilateral macronodular adrenal hyperplasias (BMAHs) causing Cushing's syndrome. In the present study, we have evaluated the role of glucagon in the regulation of cortisol secretion in 13 patients with BMAH or adrenocortical adenoma causing subclinical or overt Cushing's syndrome. Injection of glucagon provoked an increase in plasma cortisol in 2 patients. After surgery, immunohistochemical studies showed the presence of glucagon receptor-like immunoreactivity in clusters of spongiocytic cells in adrenal tissues from patients who were sensitive in vivo to glucagon. We also observed an in vitro cortisol response to vasoactive intestinal peptide from an adenoma, which was insensitive to glucagon and pituitary adenylate cyclase-activating peptide. Altogether, our data show that ectopic glucagon receptors are expressed in some adrenal cortisol-producing benign lesions. Our results also indicate that circulating glucagon may influence cortisol release under fasting conditions.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology / Endocrinology and metabolism

Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01931119
Contributor : Céline Duparc <>
Submitted on : Thursday, November 22, 2018 - 2:34:47 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:34 AM

Abnormal Sensitivity to Glucagon and Related Peptides in Primary Adrenal Cushing’s Syndrome

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Abnormal Sensitivity to Glucagon and Related Peptides in Primary Adrenal Cushing’s Syndrome

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