Impact of sodium chloride on the expansion of a liquid-liquid miscibility gap in an API/water system. Case study of Brivaracetam

Nicolas Couvrat (1) , Julien Mahieux (2) , Baptiste Fours (3) , Yohann Cartigny (1) , Eric Schenkel (4) , Luc Aerts (4) , Luc Quéré (4) , Gérard Coquerel (1)

1 SMS - Sciences et Méthodes Séparatives
2 Nestlé Research Center | Centre de recherche Nestlé [Lausanne]
3 MINAKEM SAS, 145 Chemin des Lilas, 59310 Beuvry la Foret, France -
4 UCB Pharma S.A.[Braine-l'Alleud]

Domaines: Chimie; Cristallographie; Chimie organique; Matériaux; Chimie thérapeutique

Nicolas Couvrat, Julien Mahieux, Baptiste Fours, Yohann Cartigny, Eric Schenkel, et al.. Impact of sodium chloride on the expansion of a liquid-liquid miscibility gap in an API/water system. Case study of Brivaracetam. International Journal of Pharmaceutics, 2016, 515 (1-2), pp.702 - 707. ⟨10.1016/j.ijpharm.2016.11.003⟩. ⟨hal-01928640⟩