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Dysregulation of Aldosterone Secretion in Mast Cell–Deficient Mice

Abstract : Resident adrenal mast cells have been shown to activate aldosterone secretion in rat and man. Especially, mast cell proliferation has been observed in adrenal tissues from patients with aldosterone-producing adrenocortical adenoma. In the present study, we show that the activity of adrenal mast cells is stimulated by low-sodium diet and correlates with aldosterone synthesis in C57BL/6 and BALB/c mice. We have also investigated the regulation of aldosterone secretion in mast cell-deficient C57BL/6 KitW-sh/W-sh mice in comparison with wild-type C57BL/6 mice. KitW-sh/W-sh mice submitted to normal sodium diet had basal plasma aldosterone levels similar to those observed in wild-type animals. Conversely, low-sodium diet unexpectedly induced an exaggerated aldosterone response, which seemed to result from an increase in adrenal renin and angiotensin type 1 receptor expression. Severe hyperaldosteronism was associated with an increase in systolic blood pressure and marked hypokalemia, which favored polyuria. Adrenal renin and angiotensin type 1 receptor overexpression may represent a compensatory mechanism aimed at activating aldosterone production in the absence of mast cells. Finally, C57BL/6 KitW-sh/W-sh mice represent an unexpected animal model of primary aldosteronism, which has the particularity to be triggered by sodium restriction.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01928604
Contributor : Sylvie Renouf <>
Submitted on : Tuesday, November 20, 2018 - 4:10:12 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM

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Hadrien-Gaël Boyer, Julien Wils, Sylvie Renouf, Arnaud Arabo, Céline Duparc, et al.. Dysregulation of Aldosterone Secretion in Mast Cell–Deficient Mice. Hypertension, American Heart Association, 2017, 70 (6), pp.1256 - 1263. ⟨10.1161/HYPERTENSIONAHA.117.09746⟩. ⟨hal-01928604⟩

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