Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol

Benjamin Schammé (1) , Nicolas Couvrat (1) , Pascal Malpeli , Emeline Dudognon (2) , Laurent Delbreilh (3) , Valérie Dupray (1) , Eric Dargent (3) , Gérard Coquerel (1)

1 SMS - Sciences et Méthodes Séparatives
2 UMET - Unité Matériaux et Transformations - UMR 8207
3 AMME-LECAP EA 4528 International Laboratory - Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères

Domains: Chemical Sciences; Chemical Sciences; Material chemistry; Chemical Sciences; Organic chemistry; Chemical Sciences; Theoretical and/or physical chemistry; Chemical Sciences; Medicinal Chemistry

Benjamin Schammé, Nicolas Couvrat, Pascal Malpeli, Emeline Dudognon, Laurent Delbreilh, et al.. Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol. International Journal of Pharmaceutics, 2016, 499 (1-2), pp.67 - 73. ⟨10.1016/j.ijpharm.2015.12.032⟩. ⟨hal-01928396⟩