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Late-Stage Sulfoximination: Improved Synthesis of the Anticancer Drug Candidate Atuveciclib

Abstract : An efficient synthesis of racemic atuveciclib was accomplished in five steps with an excellent 51% overall yield, using cheap reagents and mild reaction conditions. The key sulfoximination reaction was realized during the last step of the synthesis from the corresponding sulfide.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01926262
Contributor : Vincent Reboul <>
Submitted on : Monday, November 19, 2018 - 10:21:17 AM
Last modification on : Wednesday, July 1, 2020 - 12:44:31 PM

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Thomas Glachet, Xavier Franck, Vincent Reboul. Late-Stage Sulfoximination: Improved Synthesis of the Anticancer Drug Candidate Atuveciclib. SYNTHESIS, Georg Thieme Verlag, 2019, 51 (4), pp.971-975. ⟨10.1055/s-0037-1610316⟩. ⟨hal-01926262⟩

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