Intraadrenal Corticotropin in Bilateral Macronodular Adrenal Hyperplasia

Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia.

Estelle Louiset (1, 2, 3) , Céline Duparc (3, 2) , Jacques Young (4) , Sylvie Renouf (2, 1) , Milène Tetsi Nomigni (1) , Isabelle Boutelet (3) , Rossella Libé (5) , Zakariae Bram (1) , Lionel Groussin (5, 6, 7, 8, 9) , Philippe Caron (10) , Antoine Tabarin (11) , Fabienne Grunenberger , Sophie Christin-Maitre (12) , Xavier Bertagna (5, 7, 6, 8, 9) , Jean-Marc Kuhn (1) , Youssef Anouar (1) , Jerome Bertherat (5, 6, 8, 7, 9) , Hervé P. Lefebvre (2, 1)

1 DC2N - Différenciation et communication neuronale et neuroendocrine
2 DC2N - Différenciation et communication neuronale et neuroendocrine
3 Neuroendocrinologie cellulaire et moléculaire
4 Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique
5 IC UM3 (UMR 8104 / U1016) - Institut Cochin
6 Hôpital Cochin [AP-HP]
7 EMD - [Institut Cochin] Département Endocrinologie, métabolisme, diabète (EMD)
8 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
9 UPD5 - Université Paris Descartes - Paris 5
10 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
11 Departement Endocrinologie
12 CHU Saint-Antoine [AP-HP]

Bilateral macronodular adrenal hyperplasia is a rare cause of primary adrenal Cushing's syndrome. In this form of hyperplasia, hypersecretion of cortisol suppresses the release of corticotropin by pituitary corticotrophs, which results in low plasma corticotropin levels. Thus, the disease has been termed corticotropin-independent macronodular adrenal hyperplasia. We examined the abnormal production of corticotropin in these hyperplastic adrenal glands.

Domains: Life Sciences [q-bio]; Human health and pathology; Endocrinology and metabolism; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology

Estelle Louiset, Céline Duparc, Jacques Young, Sylvie Renouf, Milène Tetsi Nomigni, et al.. Intraadrenal Corticotropin in Bilateral Macronodular Adrenal Hyperplasia. New England Journal of Medicine, 2013, 369 (22), pp.2115 - 2125. ⟨10.1056/NEJMoa1215245⟩. ⟨hal-01908272⟩