A thermodynamically consistent phase diagram of a trimorphic pharmaceutical, l -tyrosine ethyl ester, based on limited experimental data

Ivo B. Rietveld (1, 2, 3) , Alain Polian (4) , Josep-Lluis Tamarit (5) , Béatrice Nicolaï (2, 6) , Maria Barrio (5) , Pol Lloveras (5) , Jean-Paul Itié (7)

1 SMS - Sciences et Méthodes Séparatives
2 UPD5 Pharmacie - Université Paris Descartes - Faculté de Pharmacie de Paris
3 USPC - Université Sorbonne Paris Cité
4 IMPMC - Institut de minéralogie, de physique des matériaux et de cosmochimie
5 GCM - Grup de Caracteritzacio de Materials, Departament de Fisica i Enginyeria Nuclear
6 IGPS - Institut Galien Paris-Sud
7 SSOLEIL - Synchrotron SOLEIL

Keywords: phase diagram; phase behavior; polymorphism; thermodynamics

Domains: Chemical Sciences; Theoretical and/or physical chemistry; Chemical Sciences; Analytical chemistry; Chemical Sciences; Material chemistry

Ivo B. Rietveld, Alain Polian, Josep-Lluis Tamarit, Béatrice Nicolaï, Maria Barrio, et al.. A thermodynamically consistent phase diagram of a trimorphic pharmaceutical, l -tyrosine ethyl ester, based on limited experimental data. Physical Chemistry Chemical Physics, 2018, 20, pp.24074-24087. ⟨10.1039/c8cp01813h⟩. ⟨hal-01877390⟩