Skip to Main content Skip to Navigation
Journal articles

A novel amphiphilic pH-sensitive hydrogel based on pullulan

Abstract : Novel polyelectrolyte and amphiphilic hydrogels based on pullulan have been prepared using 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide hydrochloride and N-hydroxysuccinimide. The cross-linking reaction is fast and lead to zero length ester cross-links by the reaction of a carboxylate group with an alcohol function of the polysaccharide. The charge density and the hydrophobic rate of the precursor carboxymethylpullulan (CMP) are controlled during the carboxymethylation of pullulan and the grafting reaction of octyl chains on CMP, respectively. The grafting degree influences the conformation of the hydrophobically modified CMP (HMCMP) in solution and leads to the formation of hydrophobic clusters firstly in the HMCMP solutions and further in the HMCMP hydrogels. The swelling measurements of HMCMP hydrogels at different salt concentrations (0–0.2 M NaCl) and different pH (3–11) shows the ionic strength and pH sensitivity of the gels. The loading of a hydrophobic probe molecule can be controlled by the grafting degree of HMCMP hydrogels.
Document type :
Journal articles
Complete list of metadata
Contributor : Didier LE CERF Connect in order to contact the contributor
Submitted on : Thursday, September 6, 2018 - 11:12:43 AM
Last modification on : Tuesday, October 19, 2021 - 4:14:12 PM

Links full text



Virginie Dulong, Georgeta Mocanu, Didier Le Cerf. A novel amphiphilic pH-sensitive hydrogel based on pullulan. Colloid and Polymer Science, Springer Verlag, 2007, 285 (10), pp.1085 - 1091. ⟨10.1007/s00396-007-1655-3⟩. ⟨hal-01869070⟩



Record views