Associative pullulan gels and their interaction with biological active substances

G Mocanu (1) , D Mihai (1) , L. Picton (2) , D Lecerf (2) , G Muller (2)

1 “Petru Poni” Institute of Macromolecular Chemistry
2 PBM - Polymères, biopolymères, membranes

This paper studies the synthesis and properties of anionic and/or amphiphilic pullulan microparticles crosslinked with epichlorohydrine or with sodium trimethaphosphate. The polysaccharide gels were physicochemically characterized and their interaction with enzymes (lysozyme) was studied with the aim to appreciate the performances for separation/purification/immobilization of the enzymes or controlled release drug systems.

Mots clés: lysozyme; Immobilized; Crosslinked carboxymethylpullulan; Hydrophobically modified polysaccharides

Domaines: Chimie; Polymères

G Mocanu, D Mihai, L. Picton, D Lecerf, G Muller. Associative pullulan gels and their interaction with biological active substances. Journal of Controlled Release, 2002, 83 (1), pp.41 - 51. ⟨10.1016/s0168-3659(02)00169-4⟩. ⟨hal-01866913⟩