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Carboxymethylpullulan hydrogels with a ionic and/or amphiphilic behavior: Swelling properties and entrapment of cationic and/or hydrophobic molecules

Abstract : New ionic and amphiphilic polysaccharide-based hydrogels were synthesized and evaluated for controlled release entrapment applications. The starting polysaccharide (pullulan) was first carboxymethylated to provide ionic derivatives. The hydrogels were then obtained by cross-linking carboxymethylpullulan with adipic acid dihydrazide in water in the presence of 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide hydrochloride (EDCI) as reagent. A set of hydrogels differing by their cross-linking densities was prepared and their degree of swelling were measured in water and in the presence of sodium chloride (0.1 mol L−1). The entrapment capacity of hydrogels was estimated using two probe molecules: methylene blue, a cationic dye with a high affinity with negatively charged compounds and coomassy brilliant blue, a molecule having a marked amphiphilic character. The ionic and/or amphiphilic properties of the hydrogels were then demonstrated by their capacity or not to entrap these molecules.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01866843
Contributor : Luc Picton <>
Submitted on : Monday, September 3, 2018 - 4:28:18 PM
Last modification on : Wednesday, December 4, 2019 - 11:18:02 AM

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V. Dulong, D. Le Cerf, L. Picton, G. Muller. Carboxymethylpullulan hydrogels with a ionic and/or amphiphilic behavior: Swelling properties and entrapment of cationic and/or hydrophobic molecules. Colloids and Surfaces A: Physicochemical and Engineering Aspects, Elsevier, 2006, 274 (1-3), pp.163 - 169. ⟨10.1016/j.colsurfa.2005.08.045⟩. ⟨hal-01866843⟩

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