High-resolution nuclear magnetic resonance spectroscopy studies of polysaccharides crosslinked by sodium trimetaphosphate: a proposal for the reaction mechanism

Stéphane Lack (1) , Virginie Dulong (1) , Luc Picton (1) , Didier Le Cerf (1) , Eric Condamine (2)

1 PBM - Polymères, biopolymères, membranes
2 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

An NMR spectroscopy study (31P, 1H, 13C) of the postulated crosslinking mechanism of sodium trimetaphosphate (STMP) on polysaccharides is reported using methyl α-d-glucopyranoside as a model. In a first step, reaction of STMP with Glc-OMe gives grafted sodium tripolyphosphate (STPPg). On the one hand, STTPg can react with a second alcohol functionality to give a crosslinked monophosphate. On the other hand, a monophosphate (grafted phosphate) could be obtained by alkaline degradation of STPPg. NMR spectroscopy allows to detect the various species formed and to obtain the crosslinking density of STMP–polysaccharides hydrogels.

Keywords: Pullulan; Hydrogels; Crosslinking mechanism; Sodium trimetaphosphate; 31P Nuclear magnetic resonance spectroscopy

Domains: Chemical Sciences; Chemical Sciences; Polymers

Stéphane Lack, Virginie Dulong, Luc Picton, Didier Le Cerf, Eric Condamine. High-resolution nuclear magnetic resonance spectroscopy studies of polysaccharides crosslinked by sodium trimetaphosphate: a proposal for the reaction mechanism. Carbohydrate Research, 2007, 342 (7), pp.943-953. ⟨10.1016/j.carres.2007.01.011⟩. ⟨hal-01866833⟩