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Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines)

Georgeta Mocanu 1 Doina Mihai 1 Misu Moscovici 2 Luc Picton 3 Didier Lecerf 3
1 “Petru Poni” Institute of Macromolecular Chemistry
2 ICCF - National Institute for Chemical-Pharmaceutical Research and Development
3 PBS - Polymères Biopolymères Surfaces
Abstract : Microparticles of curdlan, synthesized through crosslinking with epichlorohydrin in organic suspension media, were chemically modified with the aim of introducing strongly and/or weakly acidic anionic and palmitoyl hydrophobic groups. Microparticles of both curdlan and curdlan derivatives were physico-chemically characterized. Study of the interaction with enzymes, such as lysozyme, and vaccines, such as tetanus anatoxin, showed a co-operative protein retention effect, induced by electrostatic and hydrophobic forces. The results of the in vitro release studies on support–protein complexes recommend them as potential controlled release systems.
Keywords : Curdlan Microparticles Lysozyme Tetanus anatoxin Controlled release systems
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Journal articles
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01866796
Contributor : Luc Picton <>
Submitted on : Monday, September 3, 2018 - 4:13:10 PM
Last modification on : Thursday, July 2, 2020 - 3:28:57 AM

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COMUE-NORMANDIE | CNRS | INSA-ROUEN | UNIROUEN | INSA-GROUPE | PBS | ENSICAEN | UNILEHAVRE | UNICAEN

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Georgeta Mocanu, Doina Mihai, Misu Moscovici, Luc Picton, Didier Lecerf. Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines). International Journal of Biological Macromolecules, Elsevier, 2009, 44 (3), pp.215 - 221. ⟨10.1016/j.ijbiomac.2008.12.005⟩. ⟨hal-01866796⟩

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