Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones

Alexis Lator; Sylvain Gaillard; Albert Poater; Jean-Luc Renaud

doi:10.1002/chem.201800995

Journal articles

Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones

Alexis Lator ¹ Sylvain Gaillard ¹ Albert Poater ² Jean-Luc Renaud ¹

1 LCMT - Laboratoire de chimie moléculaire et thioorganique

2 UdG - Universitat de Girona

Abstract : An iron‐catalyzed chemo‐ and diastereoselective reduction of α,β‐unsaturated ketones into the corresponding saturated ketones in mild reaction conditions is reported herein. DFT calculations and experimental work underline that transfer hydride reduction is a more facile process than hydrogenation, unveiling the fundamental role of the base.

Keywords : catalysis iron complexes ligand-assisted reactions reduction unsaturated ketones

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01850332
Contributor : Jocelyne Levillain <>
Submitted on : Friday, July 27, 2018 - 11:28:04 AM
Last modification on : Thursday, July 2, 2020 - 3:21:27 AM

Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones

Identifiers

Collections

Citation

Export

Metrics

49

Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones

Identifiers

Collections

Citation

Export

Share

Metrics

49