An organocatalytic access to spiro[4.5]decanes and spiro[4.6]undecanes containing aminolactones and 3-aminopyrrolidines
Abstract
The organocatalyzed Mannich coupling of cyclic carboxaldehydes allowed the concise and simple preparation of spirocyclic aminolactones. Their conversion into pharmaceutically relevant spiro[4.5]cyclic and spiro[4.6]cyclic 3-aminopyrrolidines is also described.