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Article Dans Une Revue Dyes and Pigments Année : 2017

Fluorescent anticancer quinazolines as molecular probes for ß-tubulin colchicine site competition assay and visualization of microtubules as intracellular targeting sites

Résumé

Anticancer 2-aminoquinazolines were evaluated by their photophysical properties responding to media changes. By binding to the colchicine binding site of β-tubulin, the fluorescence emission of 2-N-morpholino-derivative (1) was blue-shifted with enhanced intensity. These distinguished features were used for the development of a β-tubulin colchicine site competition assay and visualization of the intracellular distribution of 1 by fluorescence microscopy.
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hal-01844346 , version 1 (19-07-2018)

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Yumiko Suzuki, Jun-Ichi Sawada, Paulina Hibner, Hirosuke Ishii, Kenji Matsuno, et al.. Fluorescent anticancer quinazolines as molecular probes for ß-tubulin colchicine site competition assay and visualization of microtubules as intracellular targeting sites. Dyes and Pigments, 2017, 145, pp.233-238. ⟨10.1016/j.dyepig.2017.05.050⟩. ⟨hal-01844346⟩
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