Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability

Steven C.L. Ho (1, 2) , Esther Y.C. Koh (1) , Miranda van Beers (1) , Monika Mueller (1) , Corrine Wan (1) , Gavin Teo (1) , Zhiwei Song (1) , Yen Wah Tong (2) , Muriel Bardor (3, 1) , Yuansheng Yang (1)

1 A*STAR - Agency for science, technology and research [Singapore]
2 NUS - National University of Singapore
3 Glyco-MEV - Laboratoire de Glycobiologie et Matrice Extracellulaire Végétale

Domaines: Polymères; Amélioration des plantes; Biologie moléculaire; Génomique, Transcriptomique et Protéomique [q-bio.GN]; Réseaux moléculaires [q-bio.MN]; Phytopathologie et phytopharmacie; Biotechnologies; Gamétogenèse; Organisation et fonctions cellulaires [q-bio.SC]; Interactions cellulaires [q-bio.CB]; Biochimie [q-bio.BM]

Steven C.L. Ho, Esther Y.C. Koh, Miranda van Beers, Monika Mueller, Corrine Wan, et al.. Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability. Journal of Biotechnology, 2013, 165 (3-4), pp.157 - 166. ⟨10.1016/j.jbiotec.2013.03.019⟩. ⟨hal-01843943⟩