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Journal articles
Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis
Abstract : An efficient enantioselective Michael reaction of readily available α‐substituted N‐Boc isoxazolidin‐5‐ones is described under phase transfer conditions with up to 95:5 er. The organocatalytic process is promoted by a low catalytic loading of a commercially available N‐spiro quaternary ammonium salt. This sequence opens an entry to chiral heterocyclic platforms displaying a β‐amino carbonyl motif with an α‐all‐carbon quaternary stereogenic center. The methodology was also successfully extended to the asymmetric amination reaction using an azodicarboxylate electrophile.
https://hal-normandie-univ.archives-ouvertes.fr/hal-01830254
Contributor : Jocelyne Levillain Connect in order to contact the contributor
Submitted on : Wednesday, July 4, 2018 - 5:56:57 PM
Last modification on : Tuesday, January 4, 2022 - 4:20:23 AM
Contributor : Jocelyne Levillain Connect in order to contact the contributor
Submitted on : Wednesday, July 4, 2018 - 5:56:57 PM
Last modification on : Tuesday, January 4, 2022 - 4:20:23 AM
