Borinic acid catalysed peptide synthesis

Tharwat Mohy El Dine (1) , Jacques Rouden (1) , Jérôme Blanchet (1)

1 LCMT - Laboratoire de chimie moléculaire et thioorganique

The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly efficient for peptide bond synthesis affording dipeptides in good yields without detectable racemization.

Domaines: Chimie organique; Catalyse

Tharwat Mohy El Dine, Jacques Rouden, Jérôme Blanchet. Borinic acid catalysed peptide synthesis. Chemical Communications, 2015, 51 (89), pp.16084-16087. ⟨10.1039/c5cc06177f⟩. ⟨hal-01793138⟩