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Journal Articles Chemistry - A European Journal Year : 2016

Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions

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Abstract

A highly efficient and mild transamidation of amides with amines co‐catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral α‐amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron‐derived Lewis acidity rather than an improved Brønsted acidity of acetic acid.

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hal-01793137 , version 1 (16-05-2018)

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Tharwat Mohy el dine, David Evans, Jacques Rouden, Jérôme Blanchet. Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions. Chemistry - A European Journal, 2016, 22 (17), pp.5894 - 5898. ⟨10.1002/chem.201600234⟩. ⟨hal-01793137⟩
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