Skip to Main content Skip to Navigation
Journal articles

Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions

Abstract : A highly efficient and mild transamidation of amides with amines co‐catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral α‐amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron‐derived Lewis acidity rather than an improved Brønsted acidity of acetic acid.
Document type :
Journal articles
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01793137
Contributor : Jérôme Blanchet <>
Submitted on : Wednesday, May 16, 2018 - 11:24:16 AM
Last modification on : Thursday, July 2, 2020 - 3:21:34 AM

Links full text

Identifiers

Citation

Tharwat Mohy el dine, David Evans, Jacques Rouden, Jérôme Blanchet. Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions. Chemistry - A European Journal, Wiley-VCH Verlag, 2016, 22 (17), pp.5894 - 5898. ⟨10.1002/chem.201600234⟩. ⟨hal-01793137⟩

Share

Metrics

Record views

64