Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines - Archive ouverte HAL Access content directly
Journal Articles Chemistry - A European Journal Year : 2017

Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines

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Abstract

A reduction of various aryl, alkyl, and α,β‐unsaturated amides with phenylsilane, catalysed by a borinic acid, is reported. The unprecedented reaction was carried out under very mild conditions and led to useful amines. Furthermore, the reaction tolerates a variety of functional groups. Initial investigations implicated that an intermediate diarylhydroborane is involved in the reaction mechanism.
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hal-01793130 , version 1 (16-05-2018)

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Aurélien Chardon, Tharwat Mohy el dine, Rémi Legay, Michaël de Paolis, Jacques Rouden, et al.. Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines. Chemistry - A European Journal, 2017, 23 (9), pp.2005-2009. ⟨10.1002/chem.201604802⟩. ⟨hal-01793130⟩
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