Skip to Main content Skip to Navigation
Journal articles

Monoclonal Antibodies against Human Factor VIII Molecular Neutralize Antihemophilic Factor and Ristocetin Cofactor Activities.

Brigitte Sola 1 Avner P 1 Sultan Y 1 Jeanneau C 1 Maisonneuve P 1
1 Inserm U152 - Immunologie et virologie des cancers. Immunologie des interactions cellulaires et moléculaires
Abstract : A series of monoclonal antibodies have been raised against a preparation of the factor VIII/von Willebrand factor molecule. Of the seven hybridomas showing specific activity against the factor VIII molecule in a solid-phase radioimmunoassay, three (F4.55, F4.77, and F4.264) have been shown to partially inhibit ristocetin-induced platelet aggregation and two (F4.115 and F4.415) inhibit the antihemophilic activity of the factor VIII molecule. An additional monoclonal antibody was directed against a contaminant of the factor VIII preparation and is an antifibrinogen antibody.
Document type :
Journal articles
Complete list of metadatas
https://hal-normandie-univ.archives-ouvertes.fr/hal-01762075
Contributor : Université Normandie <>
Submitted on : Monday, April 9, 2018 - 3:53:59 PM
Last modification on : Friday, October 4, 2019 - 12:05:40 PM

Links full text

openaccess

Identifiers

Collections

COMUE-NORMANDIE

Citation

Brigitte Sola, Avner P, Sultan Y, Jeanneau C, Maisonneuve P. Monoclonal Antibodies against Human Factor VIII Molecular Neutralize Antihemophilic Factor and Ristocetin Cofactor Activities.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 1982, ⟨10.1073/pnas.79.1.183⟩. ⟨hal-01762075⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

81