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Isolation and Characterization of a Monoclonal Antibody Specific for Fibrinogen and Fibrin of Human Origin.

Brigitte Sola 1 Avner Pr 1 Zilber Mt 1 Connan F 1 D. Lévy 1
1 Inserm U152 - Immunologie et virologie des cancers. Immunologie des interactions cellulaires et moléculaires
Abstract : A hybridoma cell line secreting a monoclonal antibody directed against human fibrinogen has been isolated. The antigenic determinant recognized is present on both the fibrinogen and fibrin molecules but is apparently absent from the D and E fragments and from fibrinopeptides A and B. The antibody seems to recognize a conformational structure present in native fibrinogen and in which several or possibly all the fibrinogen polypeptide chains may participate.
Keywords : hybridoma fibrinogen fibrin monoclonal antibody
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Journal articles
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01762072
Contributor : Université Normandie <>
Submitted on : Monday, April 9, 2018 - 3:53:55 PM
Last modification on : Thursday, March 19, 2020 - 12:32:02 PM

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Brigitte Sola, Avner Pr, Zilber Mt, Connan F, D. Lévy. Isolation and Characterization of a Monoclonal Antibody Specific for Fibrinogen and Fibrin of Human Origin.. Thrombosis Research, Elsevier, 1983, ⟨10.1016/0049-3848(83)90219-0⟩. ⟨hal-01762072⟩

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