Skip to Main content Skip to Navigation
Journal articles

C-Jun and Cyclin D1 Proteins as Mediators of Neuronal Death after a Focal Ischaemic Insult.

Abstract : C-JUN, a transcriptional activator, as well as cyclin D1, a key regulator of the cell cycle, have been described in vitro as mediators of programmed neuronal death. After trophic factor deprivation, the activation of c-jun and cyclin D1 genes is considered as a necessary step within the cellular machinery that leads to cell death. We show here that both c-Jun and cyclin D1 proteins are present in neurones within the infarcted area after experimental cerebral ischaemia in the mouse. Since their presence was associated with DNA fragmentation revealed by the TUNEL procedure, we propose that c-Jun and cyclin D1 are involved in the process of neuronal death.
Document type :
Journal articles
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01762051
Contributor : Université Normandie <>
Submitted on : Monday, April 9, 2018 - 3:53:08 PM
Last modification on : Thursday, March 19, 2020 - 12:40:02 PM

Identifiers

Collections

Citation

Guégan C, V. Lévy, David Jp, Ajchenbaum-Cymbalista F, Brigitte Sola. C-Jun and Cyclin D1 Proteins as Mediators of Neuronal Death after a Focal Ischaemic Insult.. NeuroReport, Lippincott, Williams & Wilkins, 1997, 8 (4), pp.1003-1007. ⟨10.1097/00001756-199703030-00037⟩. ⟨hal-01762051⟩

Share

Metrics

Record views

293