Skip to Main content Skip to Navigation
New interface
Journal articles

Reduction of Ischemic Damage in NGF-Transgenic Mice: Correlation with Enhancement of Antioxidant Enzyme Activities.

Abstract : If permanent focal ischemia is induced by middle cerebral artery occlusion (MCAO), neurons within the infarcted territory die by necrosis and apoptosis (or programmed cell death). We have previously shown, using a mouse strain transgenic (tg) for the nerve growth factor (NGF) gene, that tg mice have consistently smaller infarcted areas than wild-type (wt) animals, correlated with upregulated NGF synthesis and impaired apoptotic cell death. We studied, in wt and tg mice subjected to MCAO, the activities of several antioxidant enzymes and the synthesis of the proteins of the Bcl-2 family. Our results show that the antiapoptotic Bcl-2 protein and glutathione peroxidase are recruited after MCAO. NGF-tg mice also had an intrinsic resistance to oxidative stress because their basal copper zinc superoxide dismutase (SOD) and glutathione transferase activities were high. Additionally, manganese SOD activity increased in NGF-tg mice after MCAO, correlating strongly with the resistance of these mice to apoptosis.
Document type :
Journal articles
Complete list of metadata

https://hal-normandie-univ.archives-ouvertes.fr/hal-01762043
Contributor : Université Normandie Connect in order to contact the contributor
Submitted on : Monday, April 9, 2018 - 3:52:25 PM
Last modification on : Thursday, October 20, 2022 - 3:10:07 PM

Links full text

Identifiers

Collections

Citation

Guégan C, Ceballos-Picot I, Chevalier E, Nicole A, Onténiente B, et al.. Reduction of Ischemic Damage in NGF-Transgenic Mice: Correlation with Enhancement of Antioxidant Enzyme Activities.. Neurobiology of Disease, 1999, 6 (3), pp.180-189. ⟨10.1006/nbdi.1999.0240⟩. ⟨hal-01762043⟩

Share

Metrics

Record views

40