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Upstream Mediators of the Fas Apoptotic Transduction Pathway Are Defective in B-Chronic Lymphocytic Leukemia

Abstract : Data concerning the presence and the functionality of Fas receptor in malignant B-cells are controversial. We have analyzed Fas molecules on B-cells from patients with B-chronic lymphocytic leukemia (B-CLL) cells. We observed a large variability, both of percentage of Fas-positive cells and of intensity of Fas level. Fas triggering was inefficient in inducing apoptosis whatever the number of Fas-positive B-cells, the amount of Fas receptors. B-cells were also resistant to etoposide treatment, but able to undergo apoptosis after dexamethasone treatment. We suggest that the Fas apoptotic pathway is altered in B-CLL patients at the initial step(s) of apoptotic machinery.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01762038
Contributor : Université Normandie <>
Submitted on : Monday, April 9, 2018 - 3:52:10 PM
Last modification on : Wednesday, December 4, 2019 - 9:52:03 AM

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Roué G, Lancry L, Duquesne F, Salaün V, Troussard X, et al.. Upstream Mediators of the Fas Apoptotic Transduction Pathway Are Defective in B-Chronic Lymphocytic Leukemia. Leukemia Research, Elsevier, 2001, 25 (11), pp.967-980. ⟨10.1016/s0145-2126(01)00063-7⟩. ⟨hal-01762038⟩

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