Skip to Main content Skip to Navigation
Journal articles

Ectopic Expression of Cyclin D1 Impairs the Proliferation and Enhances the Apoptosis of a Murine Lymphoid Cell Line

Abstract : Cyclin D1, a key regulator of the cell cycle, acts as an oncogene when over-expressed in several types of cancer. In some B-chronic lymphoproliferative disorders, the over-expression of cyclin D1 protein is thought to confer a proliferative phenotype. We have generated BaF3 pro-B cell derivatives in which cyclin D1 can be induced rapidly and reversibly in a dose-dependent manner by the hormone muristerone A. When non-expressing clones displayed the same proliferative capacity as the parental cell line, in the sub-clones, a moderate induction of cyclin D1 lengthened the proliferation rate. The over-expression of cyclin D1 had the same effects on cell proliferation but also led ultimately to cell death by apoptosis. The induction of cyclin D1 in growth factor-deprived cells as well as in anticancer drug-treated cells also reinforced the magnitude of apoptosis. Thus, the expression of cyclin D1 in lymphoid cells does not confer a proliferative advantage but rather alters the response of cells towards apoptotic stimuli in a p53-independent manner. Cell Death and Differentiation (2001) 8, 51–62.
Document type :
Journal articles
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-01762037
Contributor : Université Normandie <>
Submitted on : Monday, April 9, 2018 - 3:52:08 PM
Last modification on : Wednesday, December 4, 2019 - 9:52:03 AM

Links full text

Identifiers

Collections

Citation

Duquesne F, Florent M, Roué G, Troussard X, Brigitte Sola. Ectopic Expression of Cyclin D1 Impairs the Proliferation and Enhances the Apoptosis of a Murine Lymphoid Cell Line. Cell Death and Differentiation, Nature Publishing Group, 2001, p. 51-62. ⟨10.1038/sj.cdd.4400768⟩. ⟨hal-01762037⟩

Share

Metrics

Record views

88