The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines.

Gauduchon J (1) , Gouilleux F (2) , Maillard S (3) , Marsaud V (3) , Renoir Mj (3) , Brigitte Sola (1)

1 Laboratoire de recherche Immunopathologie et infection
2 UPJV - Université de Picardie Jules Verne
3 PCPB - Physico-chimie, pharmacotechnie, biopharmacie

Multiple myeloma (MM) is an incurable hematological malignancy for which new therapeutic strategies should be envisaged. The selective estrogen receptor modulator (SERM), 4‐hydroxy tamoxifen (4‐OHTam), in the range of 1 to 10 μM, was able to impair the cell proliferation of MM cell lines. This was achieved by blocking cells at the G1 phase of the cell cycle and by inducing apoptosis. This cellular response was observed in five out of six tested cell lines, all five expressing both α and β estrogen receptor forms. No modifications of Bcl‐2, Bcl‐X, and Bax levels were observed, as well as no changes in Pi3K/Akt and JAK/STAT pathways that are often constitutively active in these cells. The signalization of 4‐OHTam‐induced cell death needs further investigation.

Keywords: cell cycle; Bcl‐2 family; survival pathway; p53; multiple myeloma; apoptosis

Domains: Life Sciences [q-bio]

Gauduchon J, Gouilleux F, Maillard S, Marsaud V, Renoir Mj, et al.. The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines.. Annals of the New York Academy of Sciences, 2003, ⟨10.1196/annals.1299.057⟩. ⟨hal-01762034⟩