M. Blagosklonny, Molecular theory of cancer, Cancer Biology & Therapy, vol.4, issue.6, pp.621-628, 2005.
DOI : 10.4161/cbt.4.6.1818

D. Hanahan and R. Weinberg, The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000.
DOI : 10.1016/S0092-8674(00)81683-9

M. Mueller and N. Fusenig, Friends or foes ??? bipolar effects of the tumour stroma in cancer, Nature Reviews Cancer, vol.22, issue.1, pp.839-888, 2004.
DOI : 10.1200/jco.2004.22.14_suppl.3616

R. Axelrod, D. Axelrod, and K. Pienta, Evolution of cooperation among tumor cells, Proceedings of the National Academy of Sciences, vol.9, issue.5, pp.13474-13483, 2006.
DOI : 10.1517/14728222.9.6.1217

H. Coley, Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer, Cancer Treatment Reviews, vol.34, issue.4, pp.378-390, 2008.
DOI : 10.1016/j.ctrv.2008.01.007

P. Greenberg, G. Hortobagyi, T. Smith, L. Ziegler, D. Frye et al., Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer., Journal of Clinical Oncology, vol.14, issue.8, pp.2197-205, 1996.
DOI : 10.1200/JCO.1996.14.8.2197

J. Bonneterre, V. Dieras, M. Tubiana-hulin, P. Bougnoux, M. Bonneterre et al., Phase II multicentre randomised study of docetaxel plus epirubicin vs 5-fluorouracil plus epirubicin and cyclophosphamide in metastatic breast cancer, British Journal of Cancer, vol.13, issue.4 Suppl 12, pp.1466-71, 2004.
DOI : 10.1097/00001813-200207000-00013

D. Longley and P. Johnston, Molecular mechanisms of drug resistance, The Journal of Pathology, vol.1603, issue.2, pp.275-92, 2005.
DOI : 10.1111/j.1349-7006.2002.tb02176.x

H. Broxterman, K. Gotink, and H. Verheul, Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib, Drug Resistance Updates, vol.12, issue.4-5, pp.114-140, 2009.
DOI : 10.1016/j.drup.2009.07.001

A. Sparreboom, R. Danesi, Y. Ando, J. Chan, and W. Figg, Pharmacogenomics of ABC transporters and its role in cancer chemotherapy, Drug Resistance Updates, vol.6, issue.2, pp.71-84, 2003.
DOI : 10.1016/S1368-7646(03)00005-0

K. Dano, Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo, Cancer Chemother Rep, vol.56, pp.701-709, 1972.

R. Juliano and V. Ling, A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.455, issue.1, pp.152-62, 1976.
DOI : 10.1016/0005-2736(76)90160-7

B. Trock, F. Leonessa, and R. Clarke, Multidrug Resistance in Breast Cancer: a Meta-analysis of MDR1/gp170 Expression and Its Possible Functional Significance, JNCI Journal of the National Cancer Institute, vol.11, issue.3, pp.917-948, 1997.
DOI : 10.1038/bjc.1957.43

F. Leonessa and R. Clarke, ATP binding cassette transporters and drug resistance in breast cancer, Endocrine Related Cancer, vol.10, issue.1, pp.43-73, 2003.
DOI : 10.1677/erc.0.0100043
URL : http://erc.endocrinology-journals.org/content/10/1/43.full.pdf

H. Broxterman, P. Sonneveld, N. Feller, G. Ossenkoppele, D. Wahrer et al., Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity, Blood, vol.87, pp.4809-4825, 1996.

J. Meesungnoen, J. Jay-gerin, and S. Mankhetkorn, mRNA levels, resistance factor, and the efficiency of P-glycoprotein-mediated efflux of pirarubicin in multidrug-resistant K562 sublines, Canadian Journal of Physiology and Pharmacology, vol.267, issue.11, pp.1054-63, 2002.
DOI : 10.1046/j.1432-1327.2000.01030.x

S. Linn, G. Giaccone, P. Van-diest, W. Blokhuis, P. Van-der-valk et al., Prognostic relevance of P-glycoprotein expression in breast cancer, Annals of Oncology, vol.6, issue.7, pp.679-85, 1995.
DOI : 10.1093/oxfordjournals.annonc.a059284

T. Licht, H. Fiebig, K. Bross, F. Herrmann, D. Berger et al., Induction of multiple-drug resistance during anti-neoplastic chemotherapyin vitro, International Journal of Cancer, vol.11, issue.4, pp.630-637, 1991.
DOI : 10.1002/ijc.2910490427

X. Hu, A. Slater, D. Wall, P. Kantharidis, J. Parkin et al., Rapid up-regulation of mdr1 expression by anthracyclines in a classical multidrug-resistant cell line, British Journal of Cancer, vol.71, issue.5, pp.931-937, 1995.
DOI : 10.1038/bjc.1995.180

A. Molinari, L. Toccacieli, A. Calcabrini, M. Diociaiuti, M. Cianfriglia et al., Induction of P-glycoprotein expression on the plasma membrane of human melanoma cells, Anticancer Res, vol.20, pp.2691-2697, 2000.

M. Pesic, J. Markovic, D. Jankovic, S. Kanazir, I. Markovic et al., by Anticancer Drugs, Journal of Chemotherapy, vol.1990, issue.8, pp.66-73, 2006.
DOI : 10.1002/ijc.2910530517

K. Luu and J. Uchizono, P-Glycoprotein Induction and Tumor Cell-Kill Dynamics in Response to Differential Doxorubicin Dosing Strategies: A Theoretical Pharmacodynamic Model, Pharmaceutical Research, vol.31, issue.5, pp.710-715, 2005.
DOI : 10.1042/bj3550617

A. Levchenko, B. Mehta, X. Niu, G. Kang, L. Villafania et al., Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells, Proceedings of the National Academy of Sciences, vol.5, issue.9, pp.1933-1941, 2005.
DOI : 10.1016/S0074-7696(08)62230-5

A. Rafii, P. Mirshahi, M. Poupot, A. Faussat, A. Simon et al., Oncologic Trogocytosis of an Original Stromal Cells Induces Chemoresistance of Ovarian Tumours, PLoS ONE, vol.171, issue.2, p.3894, 2008.
DOI : 10.1371/journal.pone.0003894.s002

M. Bebawy, V. Combes, E. Lee, R. Jaiswal, J. Gong et al., Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells, Leukemia, vol.62, issue.9, pp.1643-1652, 2009.
DOI : 10.1371/journal.pmed.0020245

P. Hinow, L. Foll, F. Magal, P. Webb, and G. , Analysis of a Model for Transfer Phenomena in Biological Populations, SIAM Journal on Applied Mathematics, vol.70, issue.1, pp.40-62, 2009.
DOI : 10.1137/080732420
URL : https://hal.archives-ouvertes.fr/inria-00441188

J. Pasquier, L. Galas, C. Boulangé-leconte, F. Bultelle, P. Magal et al., Le Foll F: Tunneling nanotubes and microparticles as concurrent carriers for cell-to-cell P-glycopretein transfers: evidence for extragenetic acquired resistance in breast cancer cells. Workshop: progress in cellular imaging Rouen, 2010.

M. Marin, A. Poret, G. Maillet, and F. Leboulenger, Regulation of volume-sensitive Cl??? channels in multi-drug resistant MCF7 cells, Biochemical and Biophysical Research Communications, vol.334, issue.4, pp.1266-78, 2005.
DOI : 10.1016/j.bbrc.2005.07.010

Y. Zhou, M. Gottesman, and I. Pastan, The Extracellular Loop between TM5 and TM6 of P-Glycoprotein Is Required for Reactivity with Monoclonal Antibody UIC2, Archives of Biochemistry and Biophysics, vol.367, issue.1, pp.74-80, 1999.
DOI : 10.1006/abbi.1999.1221

O. Frankfurt, D. Seckinger, and E. Sugarbaker, Intercellular transfer of drug resistance, Cancer Res, vol.51, pp.1190-1195, 1991.

M. Hennessy and J. Spiers, A primer on the mechanics of P-glycoprotein the multidrug transporter, Pharmacological Research, vol.55, issue.1, pp.1-15, 2007.
DOI : 10.1016/j.phrs.2006.10.007

W. Beck, T. Grogan, C. Willman, C. Cordon-cardo, D. Parham et al., Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations, Cancer Res, vol.56, pp.3010-3030, 1996.

I. Faneyte, P. Kristel, and M. Van-de-vijver, DeterminingMDR1/P-glycoprotein expression in breast cancer, International Journal of Cancer, vol.88, issue.1, pp.114-136, 2001.
DOI : 10.1038/bjc.1998.192

O. Sanfilippo, E. Ronchi, D. Marco, C. , D. Fronzo et al., Expression of P-glycoprotein in breast cancer tissue and in vitro resistance to doxorubicin and vincristine, European Journal of Cancer and Clinical Oncology, vol.27, issue.2, pp.155-163, 1991.
DOI : 10.1016/0277-5379(91)90476-T

E. Li, R. Li, Z. Zhang, and J. Wang, Clinical significance of P-glycoprotein expression in breast cancer, Chinese Journal of Cancer Research, vol.11, pp.218-220, 1999.

M. Arnal, N. Franco, P. Fargeot, J. Riedinger, and P. Brunet-lecomte, Enhancement of mdr1 gene expression in normal tissue adjacent to advanced breast cancer, Breast Cancer Research and Treatment, vol.38, issue.Suppl.7, pp.13-20, 2000.
DOI : 10.1021/bi982236+

J. Allen, R. Brinkhuis, L. Van-deemter, J. Wijnholds, and A. Schinkel, Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance, Cancer Res, vol.60, pp.5761-5767, 2000.

P. Chaudhary, E. Mechetner, and I. Roninson, Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes, Blood, vol.80, pp.2735-2744, 1992.

V. Ferrand, M. Julian, F. Chauvet, M. Hirn, M. Bourdeaux et al., Quantitative determination of the MDR-related P-glycoprotein, Pgp 170, by a rapid flow cytometric technique, Cytometry, vol.23, issue.2, pp.120-125, 1996.
DOI : 10.1002/(SICI)1097-0320(19960201)23:2<120::AID-CYTO5>3.0.CO;2-O

V. Oleinikov, F. Fleury, A. Ianoul, S. Zaitsev, and I. Nabiev, P-glycoprotein effect on the properties of its natural lipid environment probed by Raman spectroscopy and Langmuir-Blodgett technique, FEBS Letters, vol.26, issue.20, pp.4953-4961, 2006.
DOI : 10.1016/j.tips.2005.06.001
URL : https://hal.archives-ouvertes.fr/hal-00093032

R. Carlson, B. Anderson, H. Burstein, W. Carter, S. Edge et al., Invasive Breast Cancer, Journal of the National Comprehensive Cancer Network, vol.9, issue.2, pp.246-312, 2007.
DOI : 10.6004/jnccn.2011.0016

C. Rossi, G. Gasparini, L. Canobbio, E. Galligioni, R. Volpe et al., Doxorubicin distribution in human breast cancer, Cancer Treat Rep, vol.71, pp.1221-1227, 1987.

P. Speth, P. Linssen, R. Holdrinet, and C. Haanen, Plasma and cellular Adriamycin concentrations in patients with myeloma treated with ninety-six-hour continuous infusion, Clinical Pharmacology and Therapeutics, vol.41, issue.6, pp.661-666, 1987.
DOI : 10.1038/clpt.1987.92

K. Laginha, S. Verwoert, G. Charrois, and T. Allen, Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors, Clinical Cancer Research, vol.11, issue.19, pp.6944-6953, 2005.
DOI : 10.1158/1078-0432.CCR-05-0343