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STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma

Abstract : Primary mediastinal B-cell lymphoma (PMBL) is a distinct B-cell lymphoma subtype with unique clinicopathological and molecular features. PMBL cells are characterised by several genetic abnormalities that conduct to the constitutive activation of the Janus kinase 2/signal transducer and activator of transcription 6 (JAK2/STAT6) signalling pathway. Among recurrent genetic changes in PMBL, we previously reported that the XPO1 gene encoding exportin 1 that controls the nuclear export of cargo proteins and RNAs, is mutated (p.E571K) in about 25% of PMBL cases. We therefore hypothesized that STAT6 could be a cargo of XPO1 and that STAT6 cytoplasm/nucleus shuttle could be altered in a subset of PMBL cells. Using immunocytochemistry techniques as well as the proximity ligation assay, we showed that STAT6 bound XPO1 in PBML cell lines and in HEK-293 cells genetically engineered to produce STAT6. Moreover, XPO1-mediated export of STAT6 occurs in cells expressing either a wild-type or the E571K mutated XPO1 protein.
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Contributor : Brigitte Sola Connect in order to contact the contributor
Submitted on : Wednesday, March 7, 2018 - 9:03:52 AM
Last modification on : Friday, March 11, 2022 - 6:14:02 PM
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Hadjer Miloudi, Karen Leroy, Fabrice Jardin, Brigitte Sola. STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma. Cellular Signalling, Elsevier, 2018, 46, pp.76-82. ⟨10.1016/j.cellsig.2018.02.016⟩. ⟨hal-01725066⟩



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