Skip to Main content Skip to Navigation
Journal articles

Expression of Trophic Peptides and Their Receptors in Chromaffin Cells and Pheochromocytoma

Abstract : Pheochromocytomas are catecholamine-producing tumors arising from chromaffin cells of the adrenal medulla or extra-adrenal location. Along with catechola-mines, tumoral cells produce and secrete elevated quantities of trophic peptides which are normally released in a regulated manner by the normal adrenal medulla. Among these peptides, the amounts of pituitary adenylate cyclase-activating polypeptide (PACAP), adrenomedullin (AM), and neuropeptide Y (NPY) are particularly high. These peptides can exert endocrine, paracrine or autocrine effects in numerous cell types. In particular, they have been shown to be involved in cell proliferation and survival, catechol-amine production and secretion, and angiogenesis. Some of these processes are exacerbated in pheochromocy-tomas, raising the possibility of the involvement of trophic peptides. Here, we review the expression levels of NPY, PACAP, and AM and theirs receptors in chromaffin cells and pheochromocytomas, and address their possible implication in the adrenal medulla tumorigenesis and malignant development of pheochromocytomas.
Document type :
Journal articles
Complete list of metadatas

Cited literature [70 references]  Display  Hide  Download

https://hal-normandie-univ.archives-ouvertes.fr/hal-01706432
Contributor : Laurent Yon <>
Submitted on : Friday, July 20, 2018 - 1:49:18 PM
Last modification on : Thursday, July 25, 2019 - 2:24:48 PM
Long-term archiving on: : Monday, October 1, 2018 - 1:23:51 AM

File

Thouennon Cell Mol Neurobiol 2...
Files produced by the author(s)

Identifiers

  • HAL Id : hal-01706432, version 1

Citation

Erwan Thouënnon, Alice Pierre, Laurent Yon, Youssef Anouar. Expression of Trophic Peptides and Their Receptors in Chromaffin Cells and Pheochromocytoma. Cellular and Molecular Neurobiology, Springer Verlag, 2010. ⟨hal-01706432⟩

Share

Metrics

Record views

408

Files downloads

117